RapamycinFungusV1, Main, Exploration, bibRecord, 000F34

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Identifieur interne : 000F34 ( Main/Exploration ); précédent : 000F33; suivant : 000F35

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

Auteurs : Michael A. Kennedy [Canada] ; Kenneth Gable [États-Unis] ; Karolina Niewola-Staszkowska [Suisse] ; Susana Abreu [Pays-Bas] ; Anne Johnston [Canada] ; Linda J. Harris [Canada] ; Fulvio Reggiori [Pays-Bas] ; Robbie Loewith [Suisse] ; Teresa Dunn [États-Unis] ; Steffany A L. Bennett [Canada] ; Kristin Baetz [Canada]

Source :

PLoS genetics [ 1553-7404 ] ; 2014.

RBID : pubmed:24465216

Descripteurs français

KwdFr :
- Complexe-2 cible mécanistique de la rapamycine (MeSH), Complexes multiprotéiques (biosynthèse), Complexes multiprotéiques (métabolisme), Céramides (biosynthèse), Humains (MeSH), Maladie d'Alzheimer (anatomopathologie), Maladie d'Alzheimer (métabolisme), Maladie d'Alzheimer (étiologie), Membrane cellulaire (effets des médicaments et des substances chimiques), Neurones (effets des médicaments et des substances chimiques), Peptides bêta-amyloïdes (métabolisme), Phosphatidylinositol diphosphate-4,5 (métabolisme), Phosphoryl-choline (toxicité), Phosphotransferases (Alcohol Group Acceptor) (biosynthèse), Protéines de Saccharomyces cerevisiae (biosynthèse), Saccharomyces cerevisiae (MeSH), Sérine-thréonine kinases TOR (biosynthèse), Sérine-thréonine kinases TOR (métabolisme), Transduction du signal (effets des médicaments et des substances chimiques).
MESH :
- anatomopathologie : Maladie d'Alzheimer.
- biosynthèse : Complexes multiprotéiques, Céramides, Phosphotransferases (Alcohol Group Acceptor), Protéines de Saccharomyces cerevisiae, Sérine-thréonine kinases TOR.
- effets des médicaments et des substances chimiques : Membrane cellulaire, Neurones, Transduction du signal.
- métabolisme : Complexes multiprotéiques, Maladie d'Alzheimer, Peptides bêta-amyloïdes, Phosphatidylinositol diphosphate-4,5, Sérine-thréonine kinases TOR.
- toxicité : Phosphoryl-choline.
- étiologie : Maladie d'Alzheimer.
- Complexe-2 cible mécanistique de la rapamycine, Humains, Saccharomyces cerevisiae.

English descriptors

KwdEn :
- Alzheimer Disease (etiology), Alzheimer Disease (metabolism), Alzheimer Disease (pathology), Amyloid beta-Peptides (metabolism), Cell Membrane (drug effects), Ceramides (biosynthesis), Humans (MeSH), Mechanistic Target of Rapamycin Complex 2 (MeSH), Multiprotein Complexes (biosynthesis), Multiprotein Complexes (metabolism), Neurons (drug effects), Phosphatidylinositol 4,5-Diphosphate (metabolism), Phosphorylcholine (toxicity), Phosphotransferases (Alcohol Group Acceptor) (biosynthesis), Saccharomyces cerevisiae (MeSH), Saccharomyces cerevisiae Proteins (biosynthesis), Signal Transduction (drug effects), TOR Serine-Threonine Kinases (biosynthesis), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , biosynthesis : Ceramides, Multiprotein Complexes, Phosphotransferases (Alcohol Group Acceptor), Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases.
- chemical , metabolism : Amyloid beta-Peptides, Multiprotein Complexes, Phosphatidylinositol 4,5-Diphosphate, TOR Serine-Threonine Kinases.
- drug effects : Cell Membrane, Neurons, Signal Transduction.
- etiology : Alzheimer Disease.
- metabolism : Alzheimer Disease.
- pathology : Alzheimer Disease.
- chemical , toxicity : Phosphorylcholine.
- Humans, Mechanistic Target of Rapamycin Complex 2, Saccharomyces cerevisiae.

Abstract

Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Similar to neuronal cells, intracellular accumulation of PC(O-16:0/2:0) is also toxic to Saccharomyces cerevisiae, making yeast an excellent model to decipher the pathological effects of this lipid. We previously reported that phospholipase D, a phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2)-binding protein, was relocalized in response to PC(O-16:0/2:0), suggesting that this neurotoxic lipid may remodel lipid signaling networks. Here we show that PC(O-16:0/2:0) regulates the distribution of the PtdIns(4)P 5-kinase Mss4 and its product PtdIns(4,5)P2 leading to the formation of invaginations at the plasma membrane (PM). We further demonstrate that the effects of PC(O-16:0/2:0) on the distribution of PM PtdIns(4,5)P2 pools are in part mediated by changes in the biosynthesis of long chain bases (LCBs) and ceramides. A combination of genetic, biochemical and cell imaging approaches revealed that PC(O-16:0/2:0) is also a potent inhibitor of signaling through the Target of rampamycin complex 2 (TORC2). Together, these data provide mechanistic insight into how specific disruptions in phosphocholine second messenger metabolism associated with Alzheimer's disease may trigger larger network-wide disruptions in ceramide and phosphoinositide second messenger biosynthesis and signaling which have been previously implicated in disease progression.

DOI: 10.1371/journal.pgen.1004010
PubMed: 24465216
PubMed Central: PMC3900389

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000E99
to stream Main, to step Curation: 000E99

Le document en format XML

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<country xml:lang="fr">Suisse</country>
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<author><name sortKey="Dunn, Teresa" sort="Dunn, Teresa" uniqKey="Dunn T" first="Teresa" last="Dunn">Teresa Dunn</name>
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<author><name sortKey="Baetz, Kristin" sort="Baetz, Kristin" uniqKey="Baetz K" first="Kristin" last="Baetz">Kristin Baetz</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (etiology)</term>
<term>Alzheimer Disease (metabolism)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Amyloid beta-Peptides (metabolism)</term>
<term>Cell Membrane (drug effects)</term>
<term>Ceramides (biosynthesis)</term>
<term>Humans (MeSH)</term>
<term>Mechanistic Target of Rapamycin Complex 2 (MeSH)</term>
<term>Multiprotein Complexes (biosynthesis)</term>
<term>Multiprotein Complexes (metabolism)</term>
<term>Neurons (drug effects)</term>
<term>Phosphatidylinositol 4,5-Diphosphate (metabolism)</term>
<term>Phosphorylcholine (toxicity)</term>
<term>Phosphotransferases (Alcohol Group Acceptor) (biosynthesis)</term>
<term>Saccharomyces cerevisiae (MeSH)</term>
<term>Saccharomyces cerevisiae Proteins (biosynthesis)</term>
<term>Signal Transduction (drug effects)</term>
<term>TOR Serine-Threonine Kinases (biosynthesis)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Complexe-2 cible mécanistique de la rapamycine (MeSH)</term>
<term>Complexes multiprotéiques (biosynthèse)</term>
<term>Complexes multiprotéiques (métabolisme)</term>
<term>Céramides (biosynthèse)</term>
<term>Humains (MeSH)</term>
<term>Maladie d'Alzheimer (anatomopathologie)</term>
<term>Maladie d'Alzheimer (métabolisme)</term>
<term>Maladie d'Alzheimer (étiologie)</term>
<term>Membrane cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Neurones (effets des médicaments et des substances chimiques)</term>
<term>Peptides bêta-amyloïdes (métabolisme)</term>
<term>Phosphatidylinositol diphosphate-4,5 (métabolisme)</term>
<term>Phosphoryl-choline (toxicité)</term>
<term>Phosphotransferases (Alcohol Group Acceptor) (biosynthèse)</term>
<term>Protéines de Saccharomyces cerevisiae (biosynthèse)</term>
<term>Saccharomyces cerevisiae (MeSH)</term>
<term>Sérine-thréonine kinases TOR (biosynthèse)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Ceramides</term>
<term>Multiprotein Complexes</term>
<term>Phosphotransferases (Alcohol Group Acceptor)</term>
<term>Saccharomyces cerevisiae Proteins</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term>
<term>Multiprotein Complexes</term>
<term>Phosphatidylinositol 4,5-Diphosphate</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Céramides</term>
<term>Phosphotransferases (Alcohol Group Acceptor)</term>
<term>Protéines de Saccharomyces cerevisiae</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Membrane</term>
<term>Neurons</term>
<term>Signal Transduction</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Membrane cellulaire</term>
<term>Neurones</term>
<term>Transduction du signal</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Complexes multiprotéiques</term>
<term>Maladie d'Alzheimer</term>
<term>Peptides bêta-amyloïdes</term>
<term>Phosphatidylinositol diphosphate-4,5</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Phosphorylcholine</term>
</keywords>
<keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Phosphoryl-choline</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Maladie d'Alzheimer</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Mechanistic Target of Rapamycin Complex 2</term>
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<front><div type="abstract" xml:lang="en">Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Similar to neuronal cells, intracellular accumulation of PC(O-16:0/2:0) is also toxic to Saccharomyces cerevisiae, making yeast an excellent model to decipher the pathological effects of this lipid. We previously reported that phospholipase D, a phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2)-binding protein, was relocalized in response to PC(O-16:0/2:0), suggesting that this neurotoxic lipid may remodel lipid signaling networks. Here we show that PC(O-16:0/2:0) regulates the distribution of the PtdIns(4)P 5-kinase Mss4 and its product PtdIns(4,5)P2 leading to the formation of invaginations at the plasma membrane (PM). We further demonstrate that the effects of PC(O-16:0/2:0) on the distribution of PM PtdIns(4,5)P2 pools are in part mediated by changes in the biosynthesis of long chain bases (LCBs) and ceramides. A combination of genetic, biochemical and cell imaging approaches revealed that PC(O-16:0/2:0) is also a potent inhibitor of signaling through the Target of rampamycin complex 2 (TORC2). Together, these data provide mechanistic insight into how specific disruptions in phosphocholine second messenger metabolism associated with Alzheimer's disease may trigger larger network-wide disruptions in ceramide and phosphoinositide second messenger biosynthesis and signaling which have been previously implicated in disease progression. </div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24465216</PMID>
<DateCompleted><Year>2014</Year>
<Month>06</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1553-7404</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>1</Issue>
<PubDate><Year>2014</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>PLoS genetics</Title>
<ISOAbbreviation>PLoS Genet</ISOAbbreviation>
</Journal>
<ArticleTitle>A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.</ArticleTitle>
<Pagination><MedlinePgn>e1004010</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pgen.1004010</ELocationID>
<Abstract><AbstractText>Unbiased lipidomic approaches have identified impairments in glycerophosphocholine second messenger metabolism in patients with Alzheimer's disease. Specifically, we have shown that amyloid-β42 signals the intraneuronal accumulation of PC(O-16:0/2:0) which is associated with neurotoxicity. Similar to neuronal cells, intracellular accumulation of PC(O-16:0/2:0) is also toxic to Saccharomyces cerevisiae, making yeast an excellent model to decipher the pathological effects of this lipid. We previously reported that phospholipase D, a phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2)-binding protein, was relocalized in response to PC(O-16:0/2:0), suggesting that this neurotoxic lipid may remodel lipid signaling networks. Here we show that PC(O-16:0/2:0) regulates the distribution of the PtdIns(4)P 5-kinase Mss4 and its product PtdIns(4,5)P2 leading to the formation of invaginations at the plasma membrane (PM). We further demonstrate that the effects of PC(O-16:0/2:0) on the distribution of PM PtdIns(4,5)P2 pools are in part mediated by changes in the biosynthesis of long chain bases (LCBs) and ceramides. A combination of genetic, biochemical and cell imaging approaches revealed that PC(O-16:0/2:0) is also a potent inhibitor of signaling through the Target of rampamycin complex 2 (TORC2). Together, these data provide mechanistic insight into how specific disruptions in phosphocholine second messenger metabolism associated with Alzheimer's disease may trigger larger network-wide disruptions in ceramide and phosphoinositide second messenger biosynthesis and signaling which have been previously implicated in disease progression. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kennedy</LastName>
<ForeName>Michael A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gable</LastName>
<ForeName>Kenneth</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Niewola-Staszkowska</LastName>
<ForeName>Karolina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abreu</LastName>
<ForeName>Susana</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Johnston</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Linda J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reggiori</LastName>
<ForeName>Fulvio</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Cell Biology and Institute of Biomembranes, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Loewith</LastName>
<ForeName>Robbie</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biology and Swiss National Center for Competence in Research Programme Chemical Biology, University of Geneva, Geneva, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dunn</LastName>
<ForeName>Teresa</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bennett</LastName>
<ForeName>Steffany A L</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baetz</LastName>
<ForeName>Kristin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>89999</GrantID>
<Agency>Canadian Institutes of Health Research</Agency>
<Country>Canada</Country>
</Grant>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2014</Year>
<Month>01</Month>
<Day>23</Day>
</ArticleDate>
</Article>
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<MedlineTA>PLoS Genet</MedlineTA>
<NlmUniqueID>101239074</NlmUniqueID>
<ISSNLinking>1553-7390</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016229">Amyloid beta-Peptides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D002518">Ceramides</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D046912">Multiprotein Complexes</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D019269">Phosphatidylinositol 4,5-Diphosphate</NameOfSubstance>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
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<MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName>
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<MeshHeading><DescriptorName UI="D019269" MajorTopicYN="N">Phosphatidylinositol 4,5-Diphosphate</DescriptorName>
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<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
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   |texte=   A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.
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	Serveur d'exploration sur la rapamycine et les champignons
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Serveur d'exploration sur la rapamycine et les champignons

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

A neurotoxic glycerophosphocholine impacts PtdIns-4, 5-bisphosphate and TORC2 signaling by altering ceramide biosynthesis in yeast.

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